3051552-64-5
3051552-64-5
Chemical Structure
KIF18A-IN-15
- CAS No.: 3051552-64-5
- Formula:C25H33F3N6O5S
- Molecular Weight:586.63
InChIKey: MVQDBFBUILUFDK-UHFFFAOYSA-N
SMILES: O=C1NC2=CC(C)=N/C(N2)=N/CC(COCC3(C(F)(F)F)CCN(CC3)C4=CC(NS(=O)(CCO)=O)=CC=C14)C
Biological Activity: KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, with IC50s of 0.01-0.1 μM, respectively. EX36-A and EX36-B inhibit OVCAR-3 cells viability with IC50s of 0.01-0.1 μM and 0-0.01 μM, respectively. KIF18A-IN-15 can be used in tumor (e.g. colon, breast, lung) studies[1].
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KIF18A-IN-15 | KIF18A-IN-15 (Compound Example 36) is a KIF18A inhibitor, available in two forms, EX36-A and its enantiomer EX36-B, with IC50s of 0.01-0.1 μM, respectively. EX36-A and EX36-B inhibit OVCAR-3 cells viability with IC50s of 0.01-0.1 μM and 0-0.01 μM, respectively. KIF18A-IN-15 can be used in tumor (e.g. colon, breast, lung) studies. | |||||||||||||||||||||
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References
Keywords
