254753-54-3
254753-54-3
Chemical Structure
(S)-Monastrol
Synonym(s): (+)-Monastrol
- CAS No.: 254753-54-3
- Formula:C14H16N2O3S
- Molecular Weight:292.35
IUPAC Name: ethyl (S)-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
InChIKey: LOBCDGHHHHGHFA-LBPRGKRZSA-N
SMILES: O=C(C1=C(C)NC(N[C@H]1C2=CC=CC(O)=C2)=S)OCC
Biological Activity: (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles[1][2].
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(S)-Monastrol | (S)-Monastrol ((+)-Monastrol) is an allosteric inhibitor of the mitotic kinesin Eg5 that exhibits an antiproliferative effect against several cancer cell lines. (S)-Monastrol arrests mammalian cells in mitosis with monopolar spindles. | |||||||||||||||||||||
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References
- [1]. Marques LA, et al. Antiproliferative activity of monastrol in human adenocarcinoma (MCF-7) and non-tumor (HB4a) breast cells. Naunyn Schmiedebergs Arch Pharmacol. 2016 Dec;389(12):1279-1288. [Content Brief]
- [2]. Mayer TU, et al. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286(5441):971-4. [Content Brief]
Keywords
