1. Cell Cycle/DNA Damage
    Cytoskeleton
  2. Microtubule/Tubulin
  3. KIF18A-IN-2

KIF18A-IN-2 

Cat. No.: HY-145802
Handling Instructions

KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer.

For research use only. We do not sell to patients.

KIF18A-IN-2 Chemical Structure

KIF18A-IN-2 Chemical Structure

CAS No. : 2600559-20-2

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5 mg USD 590 In-stock
Estimated Time of Arrival: December 31
10 mg USD 890 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1780 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2850 In-stock
Estimated Time of Arrival: December 31
100 mg USD 4380 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer[1].

IC50 & Target

IC50: 28 nM (KIF18A)[1]

In Vivo

KIF18A-IN-2 (compound 23) (100 mg/kg; i.p., single) exhibits a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours[1]. Pharmacokinetic Parameters of KIF18A-IN-2 in female CD-1 mice[1].

IP (100 mg/kg)
Cmax (μM) 12.6
AUC0-24 (μM·h) 147
C24h (μM) 2.9
PPB (fu) 0.007

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)[1]
Dosage: 100 mg/kg
Administration: i.p., single
Result: Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.
Molecular Weight

534.69

Formula

C25H34N4O5S2

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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KIF18A-IN-2
Cat. No.:
HY-145802
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