KIF18A-IN-2
Based on 1 Customer Validation
KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer.
For research use only. We do not sell to patients.
- Purity: 98.49%
- CAS No.: 2600559-20-2
- Formula: C25H34N4O5S2
- Molecular Weight:534.69
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Kinesin Isoforms
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Biological Activity
IC50: 28 nM (KIF18A)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| OVCAR-3 | EC50 |
0.016 μM
Compound: 23
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Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
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[PMID: 35286090] |
| OVCAR-3 | EC50 |
0.016 μM
Compound: 23
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Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
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[PMID: 35286090] |
| IP (100 mg/kg) | |
| Cmax (μM) | 12.6 |
| AUC0-24 (μM·h) | 147 |
| C24h (μM) | 2.9 |
| PPB (fu) | 0.007 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)[1]
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Dosage:100 mg/kg
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Administration:i.p., single
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Result:Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.
Chemical Information
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CAS No. 2600559-20-2
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Appearance Solid
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Molecular Weight 534.69
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Formula C25H34N4O5S2
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Color White to off-white
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SMILES
O=C(C1=CC=C(NS(C)(=O)=O)C=C1N2CCC3(CC3)CC2)NC4=CC=CC(S(NC(C)(C)C)(=O)=O)=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (93.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8702 mL | 9.3512 mL | 18.7024 mL | 46.7561 mL |
| 5 mM | 0.3740 mL | 1.8702 mL | 3.7405 mL | 9.3512 mL | |
| 10 mM | 0.1870 mL | 0.9351 mL | 1.8702 mL | 4.6756 mL | |
| 15 mM | 0.1247 mL | 0.6234 mL | 1.2468 mL | 3.1171 mL | |
| 20 mM | 0.0935 mL | 0.4676 mL | 0.9351 mL | 2.3378 mL | |
| 25 mM | 0.0748 mL | 0.3740 mL | 0.7481 mL | 1.8702 mL | |
| 30 mM | 0.0623 mL | 0.3117 mL | 0.6234 mL | 1.5585 mL | |
| 40 mM | 0.0468 mL | 0.2338 mL | 0.4676 mL | 1.1689 mL | |
| 50 mM | 0.0374 mL | 0.1870 mL | 0.3740 mL | 0.9351 mL | |
| 60 mM | 0.0312 mL | 0.1559 mL | 0.3117 mL | 0.7793 mL | |
| 80 mM | 0.0234 mL | 0.1169 mL | 0.2338 mL | 0.5845 mL |
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