KIF18A-IN-2
Based on 1 Customer Validation
KIF18A-IN-2 is a potent KIF18A inhibitor (IC50=28 nM). KIF18A-IN-2 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-2 can be used for researching cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.49%
- CAS 番号: 2600559-20-2
- 分子式: C25H34N4O5S2
- 分子量:534.69
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: 28 nM (KIF18A)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| OVCAR-3 | EC50 |
0.016 μM
Compound: 23
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Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
Antiproliferative activity against human OVCAR-3 cells by nuclear count assay
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[PMID: 35286090] |
| OVCAR-3 | EC50 |
0.016 μM
Compound: 23
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Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
Induction of mitotic arrest in human OVCAR-3 cells assessed as p-histone H3 incubated for 24 hrs by mitotic - imaging assay
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[PMID: 35286090] |
| IP (100 mg/kg) | |
| Cmax (μM) | 12.6 |
| AUC0-24 (μM·h) | 147 |
| C24h (μM) | 2.9 |
| PPB (fu) | 0.007 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female athymic nude mice (4-7 weeks; injected with human OVCAR-3 HGSOC cells)[1]
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Dosage:100 mg/kg
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Administration:i.p., single
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Result:Showed a significant and sustained pharmacodynamic response, increasing the number of mitotic cells (pH3 positive cells) in tumor tissues for up to 24 hours.
化学情報
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CAS 番号 2600559-20-2
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性状 Solid
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分子量 534.69
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分子式 C25H34N4O5S2
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Color White to off-white
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SMILES
O=C(C1=CC=C(NS(C)(=O)=O)C=C1N2CCC3(CC3)CC2)NC4=CC=CC(S(NC(C)(C)C)(=O)=O)=C4
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (93.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8702 mL | 9.3512 mL | 18.7024 mL | 46.7561 mL |
| 5 mM | 0.3740 mL | 1.8702 mL | 3.7405 mL | 9.3512 mL | |
| 10 mM | 0.1870 mL | 0.9351 mL | 1.8702 mL | 4.6756 mL | |
| 15 mM | 0.1247 mL | 0.6234 mL | 1.2468 mL | 3.1171 mL | |
| 20 mM | 0.0935 mL | 0.4676 mL | 0.9351 mL | 2.3378 mL | |
| 25 mM | 0.0748 mL | 0.3740 mL | 0.7481 mL | 1.8702 mL | |
| 30 mM | 0.0623 mL | 0.3117 mL | 0.6234 mL | 1.5585 mL | |
| 40 mM | 0.0468 mL | 0.2338 mL | 0.4676 mL | 1.1689 mL | |
| 50 mM | 0.0374 mL | 0.1870 mL | 0.3740 mL | 0.9351 mL | |
| 60 mM | 0.0312 mL | 0.1559 mL | 0.3117 mL | 0.7793 mL | |
| 80 mM | 0.0234 mL | 0.1169 mL | 0.2338 mL | 0.5845 mL |
KIF18A-IN-2 関連分類
HY-145802 関連分類
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