1146209-50-8
Chemical Structure
SCH 2047069
Synonym(s): MK-8267
- CAS No.: 1146209-50-8
- Formula:C20H17F4N3O2S
- Molecular Weight:439.43
IUPAC Name: 1-((3R,4S)-3-(2-aminoethyl)-5'-(2,5-difluorophenyl)-6,7-difluoro-3'H-spiro[chromane-4,2'-[1,3,4]thiadiazol]-3'-yl)ethan-1-one
InChIKey: FUZQTOPGYJUXHS-GIPWTMENSA-N
SMILES: CC(N1N=C(C2=CC(F)=CC=C2F)S[C@@]31[C@H](CCN)COC4=CC(F)=C(F)C=C34)=O
Biological Activity: SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (Kd: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC50 value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma[1][2].
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SCH 2047069 | SCH 2047069 (MK-8267) is an orally active kinesin spindle protein (KSP) inhibitor (Kd: 0.5 nM) that can cross the blood-brain barrier. SCH 2047069 exhibits an IC50 value of ≤ 5 nM against the KSP ATPase. SCH 2047069 exhibits broad-spectrum antitumor activity. SCH 2047069 can induce mitotic arrest and apoptosis in tumor cells. SCH 2047069 can be used in the research of tumors such as ovarian cancer, colon cancer, glioblastoma, and lymphoma. | |||||||||||||||||||||
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- [1]. Basso AD, et al. SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics. Mol Cancer Ther. 2010 Nov;9(11):2993-3002. [Content Brief]
- [2]. Nyamaa B, et al. Kinesin spindle protein inhibition in translational research. Journal of Lipid and Atherosclerosis, 2014, 3(2): 63-78.
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