2. Signaling Pathways
  3. Apoptosis
  4. MDM-2/p53
  5. MDM-2/p53 Modulator

MDM-2/p53 Modulator

MDM-2/p53 Modulators (5):

Cat. No. Product Name Effect Purity
  • HY-156967
    BAY 1892005
    		Modulator 99.44%
    BAY 1892005 is a regulator of p53 protein and acts on p53 condensates without causing mutant p53 reactivation.
  • HY-145785A
    ADH-6 TFA
    		Modulator 99.91%
    ADH-6 TFA is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 TFA targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 TFA has the potential for the research of cancer diseases.
  • HY-145937
    PK9327
    		Modulator 98.50%
    PK9327 is a small-molecule stabilizer targeting cavity-creating p53 cancer mutations.
  • HY-145759
    Mutant p53 modulator-1
    		Modulator 98.25%
    Mutant p53 modulator-1 is a mutant p53 modulator. Mutant p53 modulator-1 reduces the progression of cancers that contain a p53 mutation (extracted from patent WO2021231474A1, compound 231B).
  • HY-145785
    ADH-6
    		Modulator
    ADH-6 is a tripyridylamide compound. ADH-6 abrogates self-assembly of the aggregation-nucleating subdomain of mutant p53 DBD. ADH-6 targets and dissociates mutant p53 aggregates in human cancer cells, which restores p53's transcriptional activity, leading to cell cycle arrest and apoptosis. ADH-6 has the potential for the research of cancer diseases[1].