2. Apoptosis PI3K/Akt/mTOR Cell Cycle/DNA Damage
  3. MDM-2/p53 DNA-PK Apoptosis
  4. p53 Stabilizer 2

p53 Stabilizer 2 is a 9'-cycloheptylselenomethyl-noscapine derivative and DNA-PKcs-dependent p53 stabilizer with low tubulin-binding affinity.p53 Stabilizer 2 induces S-phase arrest and apoptosis in cancer cells.p53 Stabilizer 2 can be used for the research of cancer.

For research use only. We do not sell to patients.

p53 Stabilizer 2

p53 Stabilizer 2 Chemical Structure

CAS No. : 2531685-87-5

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p53 Stabilizer 2 Related Antibodies

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Description

p53 Stabilizer 2 is a 9'-cycloheptylselenomethyl-noscapine derivative and DNA-PKcs-dependent p53 stabilizer with low tubulin-binding affinity.p53 Stabilizer 2 induces S-phase arrest and apoptosis in cancer cells.p53 Stabilizer 2 can be used for the research of cancer[1].

In Vitro

p53 Stabilizer 2 (compound 17a16) exerts potent proliferation-inhibitory effects on various tumor cell lines including JeKo-1 and MOLM-13. The IC50 at 48 h (0.81-1.81 μM) is lower than that of normal peripheral blood mononuclear cells, conferring excellent tumor selectivity[1].
p53 Stabilizer 2 increases mitochondrial superoxide levels in A375 and JeKo-1 cells, and induces cellular oxidative stress[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

p53 Stabilizer 2 Related Antibodies

Cell Viability Assay[1]

Cell Line: MOLM-13, NB4, Jurkat, JeKo-1, K562, and A375 cell lines
Concentration: IC50 assay
Incubation Time: 48 h
Result: Exhibited IC50 values of 0.92 ± 0.04, 1.81 ± 0.03, 1.36 ± 0.10, 0.97 ± 0.03, 1.71 ± 0.60, and 0.81 ± 0.10 μM against MOLM-13, NB4, Jurkat, JeKo-1, K562, and A375 cell lines, respectively.
Molecular Weight

602.58

Formula

C30H37NO7Se
CAS No.
SMILES

O=C1O[C@H]([C@@H]2N(C)CCC3=C(C[Se]C4CCCCCC4)C5=C(OCO5)C(OC)=C23)C6=C1C(OC)=C(OC)C=C6
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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p53 Stabilizer 2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p53 Stabilizer 22531685-87-5MDM-2/p53DNA-PKApoptosisDNA-dependent protein kinasep53apoptosistubulinS-phase arrestDNA-PKcscancer cellscancerInhibitorinhibitorinhibit

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