110883-46-0
Chemical Structure
Girolline
Synonym(s): RP 49532
- CAS No.: 110883-46-0
- Formula:C6H11ClN4O
- Molecular Weight:190.63
IUPAC Name: (1S,2S)-3-amino-1-(2-amino-1H-imidazol-5-yl)-2-chloropropan-1-ol
InChIKey: YILCGOCHVFQMTC-WVZVXSGGSA-N
SMILES: NC[C@H](Cl)[C@H](C1=CN=C(N)N1)O
Biological Activity: Girolline (RP 49532) is a protein synthesis inhibitor and a functional modulator of eIF5A. Girolline induces ribosome stalling by interfering with the binding of eIF5A to ribosomes. Girolline also inhibits the production of IL-6 and IL-8, and induces cell cycle arrest in tumor cells. Girolline is applicable to research related to inflammatory diseases, solid tumors, leukemia and malaria[1][2][3][4].
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Girolline | Girolline (RP 49532) is a protein synthesis inhibitor and a functional modulator of eIF5A. Girolline induces ribosome stalling by interfering with the binding of eIF5A to ribosomes. Girolline also inhibits the production of IL-6 and IL-8, and induces cell cycle arrest in tumor cells. Girolline is applicable to research related to inflammatory diseases, solid tumors, leukemia and malaria. | |||||||||||||||||||||
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- [1]. Fung SY, et al. Unbiased screening of marine sponge extracts for anti-inflammatory agents combined with chemical genomics identifies girolline as an inhibitor of protein synthesis. ACS Chem Biol. 2014;9(1):247-257. [Content Brief]
- [2]. Tsukamoto S, et al. Girolline, an antitumor compound isolated from a sponge, induces G2/M cell cycle arrest and accumulation of polyubiquitinated p53. Biol Pharm Bull. 2004;27(5):699-701. [Content Brief]
- [3]. Diop D, et al. Girolline interferes with cell-cycle progression, but not with translation. C R Biol. 2007;330(12):855-860. [Content Brief]
- [4]. Schneider-Poetsch T, et al. Girolline is a sequence context-selective modulator of eIF5A activity. Nat Commun. 2025;16(1):223. Published 2025 Jan 10. [Content Brief]
Keywords
