421579-95-5
Chemical Structure
Anticancer agent 311
- CAS No.: 421579-95-5
- Formula:C23H18FNO5S
- Molecular Weight:439.46
InChIKey: MCWZMIDUVZXGBW-UHFFFAOYSA-N
SMILES: O=C(C1=C(C2=CC=CC=C2)OC3=C1C=C(NS(=O)(C4=CC=C(C=C4)F)=O)C=C3)OCC
Biological Activity: Anticancer agent 311 is an apoptosis inducer and p53 modulator. Anticancer agent 311 increases p53 levels, activates cleaved caspase-3, reduces p-Cdc25C levels, and disrupts p-p44/42 MAPK phosphorylation. Anticancer agent 311 induces G2/M phase arrest, inhibits cancer cell viability in a concentration- and time-dependent manner, and exhibits low toxicity to non-cancer cells. Anticancer agent 311 prevents tumor growth and angiogenesis in mouse xenograft models without detectable toxicity. Anticancer agent 311 can be used for the research of lung cancer[1].
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Anticancer agent 311 | Anticancer agent 311 is an apoptosis inducer and p53 modulator. Anticancer agent 311 increases p53 levels, activates cleaved caspase-3, reduces p-Cdc25C levels, and disrupts p-p44/42 MAPK phosphorylation. Anticancer agent 311 induces G2/M phase arrest, inhibits cancer cell viability in a concentration- and time-dependent manner, and exhibits low toxicity to non-cancer cells. Anticancer agent 311 prevents tumor growth and angiogenesis in mouse xenograft models without detectable toxicity. Anticancer agent 311 can be used for the research of lung cancer. | |||||||||||||||||||||
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Keywords
