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Src 関連製品 (225)
関連製品 (225)
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A-770041 (Standard)
0 Images製品番号: HY-11011RCAS 番号: 869748-10-7A-770041 (Standard) is the analytical standard of A-770041 (HY-11011). This product is intended for research and analytical applications. A-770041 is a selective and orally active Src-family Lck inhibitor. A-770041 inhibits Lck with an IC50 value of 147 nM with the presence of 1 mM ATP. A-770041 shows 300-fold selective to Lck over Fyn, the other Src family Kinase involved in T-cell signaling. A-770041 can be used for the research of acute rejection.
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Dasatinib hydrochloride (Standard)
0 Images別名: BMS-354825 hydrochloride (Standard)Dasatinib (hydrochloride) (Standard) is the analytical standard of Dasatinib (hydrochloride). This product is intended for research and analytical applications. Dasatinib (BMS-354825) hydrochloride is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib hydrochloride inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib hydrochloride also induces apoptosis and autophagy.
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Src Inhibitor 1 (Standard)
0 Images製品番号: HY-101053RCAS 番号: 179248-59-0別名: Src Kinase Inhibitor 1 (Standard); Src-l1 (Standard)Src Inhibitor 1 (Standard) is the analytical standard of Src Inhibitor 1 (HY-101053). This product is intended for research and analytical applications. Src Inhibitor 1 is a potent, ATP-competitive and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck.
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Elzovantinib (Standard)
0 Images製品番号: HY-111787RCAS 番号: 2271119-26-5別名: TPX-0022 (Standard); CSF1R-IN-2 (Standard)Elzovantinib (Standard) is the analytical standard of Elzovantinib (HY-111787). This product is intended for research and analytical applications. Elzovantinib (TPX-0022) is an oral-active inhibitor of SRC, MET and c-FMS, with IC50 values of 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively.
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KB SRC 4 (Standard)
0 Images製品番号: HY-108488RCAS 番号: 1380088-03-8KB SRC 4 (Standard) is the analytical standard of KB SRC 4 (HY-108488). This product is intended for research and analytical applications. KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity.
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Bafetinib (Standard)
0 Images別名: INNO-406 (Standard); NS-187 (Standard)Bafetinib (Standard) is the analytical standard of Bafetinib. This product is intended for research and analytical applications. Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph+ leukemia cells. Bafetinib has antitumor activity.
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RK-24466 (Standard)
0 Images製品番号: HY-108318RCAS 番号: 213743-31-8別名: KIN 001-51 (Standard)
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CGP062464
0 Images製品番号: HY-171218CAS 番号: 121405-24-1CGP062464 is an inhibitor of the tyrosine kinase c-Src (IC50: < 50 nM). CGP062464 can be used for research of osteoporosis and tumor-induced hypercalcemia.
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PF 477736 (Standard)
0 Images製品番号: HY-10032RCAS 番号: 952021-60-2別名: PF 00477736 (Standard)PF 477736 (Standard) is the analytical standard of PF 477736 (HY-10032). This product is intended for research and analytical applications. PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo.
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5-O-Methylvisammioside (Standard)
0 Images製品番号: HY-N0442RCAS 番号: 84272-85-5別名: 4'-O-β-D-Glucosyl-5-O-methylvisamminol (Standard)5-O-Methylvisammioside (4'-O-β-D-Glucosyl-5-O-methylvisamminol) (Standard) is the analytical standard of 5-O-Methylvisammioside. This product is intended for research and analytical applications. 5-O-Methylvisammioside is an orally active natural chromone glycoside and multiple biological activities. 5-O-Methylvisammioside inhibits ferroptosis by activating the Nrf2/HO-1 signaling axis. 5-O-Methylvisammioside alleviates intestinal barrier damage by inhibiting the ROS/NF-κB/NLRP3 pathway. 5-O-Methylvisammioside exerts a protective effect against acute liver injury by reducing ALT/AST, decreasing inflammatory infiltration, and inhibiting IκB-α phosphorylation and NF-κB nuclear translocation. 5-O-Methylvisammioside blocks the HMGB1/RAGE/MEK/ERK signaling axis to exert anti-tumor and anti-angiogenic effects. 5-O-Methylvisammioside improves depression-like behaviors by inhibiting Src kinase and the NF-κB pathway.
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Hibarimicin A
0 Images製品番号: HY-N14267CAS 番号: 208588-76-5Hibarimicin A is a tyrosine kinase inhibitor found in Microbispora rosea subsp. hibaria. Hibarimicin A selectively inhibits the activity of src tyrosine kinase without affecting protein kinase A and C. Hibarimicin A also has moderate anti-Gram-positive bacteria activity with a MIC of 0.8-12.56 μg/mL.
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2,3,4,6,8-Pentahydroxy-1-methylxanthone
0 Images製品番号: HY-N12166CAS 番号: 548740-87-02,3,4,6,8-Pentahydroxy-1-methylxanthone is a xanthone derivative of Wardomyces anomalus. 2,3,4,6,8-Pentahydroxy-1-methylxanthone shows significant antioxidant activities. 2,3,4,6,8-Pentahydroxy-1-methylxanthone is inhibitors of p56lck tyrosine kinase. 2,3,4,6,8-Pentahydroxy-1-methylxanthone can be used to research cardiovascular disease.
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Multi-kinase-IN-11
0 Images製品番号: HY-18909CAS 番号: 1157857-36-7
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Pelitinib-d6
0 Images製品番号: HY-32718SCAS 番号: 1325223-34-4
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Tirbanibulin (Standard)
0 Images別名: KX2-391 (Standard); KX-01 (Standard)
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AP22408
0 Images製品番号: HY-125064CAS 番号: 268741-43-1AP22408 is a nonpeptide inhibitor against Src SH2 with an IC50 value of 0.3 μM. AP22408 inhibits rabbit osteoclast-mediated resorption of dentine, exhibits bone-targeting properties based on a hydroxyapatite adsorption assay and demonstrates in vivo antiresorptive activity in a parathyroid hormone-induced rat model. AP22408 is proming for rasearch of osteoporosis and other bone-related diseases such as Paget’s disease, osteolytic bone metastasis and hypercalcemia associated with malignancy.
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TG 100572 hydrochloride (Standard)
0 Images製品番号: HY-10185RCAS 番号: 867331-64-4TG 100572 hydrochloride (Standard) is the analytical standard of TG 100572 hydrochloride (HY-10185). This product is intended for research and analytical applications. TG 100572 Hydrochloride is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 nM for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively.
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Rhodomycin A
0 Images製品番号: HY-N14618CAS 番号: 23666-50-4
