KB SRC 4
Based on 1 Customer Validation
KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity.
For research use only. We do not sell to patients.
- Purity: 99.22%
- CAS No.: 1380088-03-8
- Formula: C32H23ClN8
- Molecular Weight:555.03
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| HMEC | GI50 |
4.3 μM
Compound: 1
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Cytotoxicity against human HMEC after 72 hrs by WST1 assay
Cytotoxicity against human HMEC after 72 hrs by WST1 assay
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[PMID: 24015327] |
| SK-BR-3 | GI50 |
4.8 μM
Compound: 1
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Cytotoxicity against human SK-BR-3 cells after 72 hrs by WST1 assay
Cytotoxicity against human SK-BR-3 cells after 72 hrs by WST1 assay
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[PMID: 24015327] |
KB SRC 4 (Compound 4) is a potent, highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM. KB SRC 4 is selective between Src family members, with >2-fold selectivity over both Lck (Kd, 160 nM) and Fgr (Kd, 240 nM), 8-fold selectivity over c-Yes (Kd, 720 nM), and >40-fold selectivity over Lyn (Kd, 3200 nM), Hck (Kd, 4400 nM), and Fyn (Kd, >40000 nM). KB SRC 4 inhibits the growth of cancer cell lines, with GI50s of 11 μM, 12 μM, 11 μM, 6.0 μM against HT-29, SK-BR-3, MCF7, MDA-MB-453, and NIH-3T3, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1380088-03-8
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Appearance Solid
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Molecular Weight 555.03
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Formula C32H23ClN8
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Color Light brown to brown
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SMILES
NC1=C2C(N(C3=CC=CC(C4=CN=NN4CC5=CC(C6=CC=CC=C6)=CC=C5)=C3)N=C2C7=CC=C(Cl)C=C7)=NC=N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (180.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8017 mL | 9.0085 mL | 18.0170 mL | 45.0426 mL |
| 5 mM | 0.3603 mL | 1.8017 mL | 3.6034 mL | 9.0085 mL | |
| 10 mM | 0.1802 mL | 0.9009 mL | 1.8017 mL | 4.5043 mL | |
| 15 mM | 0.1201 mL | 0.6006 mL | 1.2011 mL | 3.0028 mL | |
| 20 mM | 0.0901 mL | 0.4504 mL | 0.9009 mL | 2.2521 mL | |
| 25 mM | 0.0721 mL | 0.3603 mL | 0.7207 mL | 1.8017 mL | |
| 30 mM | 0.0601 mL | 0.3003 mL | 0.6006 mL | 1.5014 mL | |
| 40 mM | 0.0450 mL | 0.2252 mL | 0.4504 mL | 1.1261 mL | |
| 50 mM | 0.0360 mL | 0.1802 mL | 0.3603 mL | 0.9009 mL | |
| 60 mM | 0.0300 mL | 0.1501 mL | 0.3003 mL | 0.7507 mL | |
| 80 mM | 0.0225 mL | 0.1126 mL | 0.2252 mL | 0.5630 mL | |
| 100 mM | 0.0180 mL | 0.0901 mL | 0.1802 mL | 0.4504 mL |
KB SRC 4 Related Classifications
HY-108488 Related Classifications
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