1. Protein Tyrosine Kinase/RTK
  2. Src
  3. KB SRC 4

KB SRC 4 

Cat. No.: HY-108488
Handling Instructions

KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity.

For research use only. We do not sell to patients.

KB SRC 4 Chemical Structure

KB SRC 4 Chemical Structure

CAS No. : 1380088-03-8

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Description

KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity.

IC50 & Target

Ki: 44 nM (c-Src)[1]
Kd: 86 nM (c-Src)[1]

In Vitro

KB SRC 4 (Compound 4) is a potent, highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM. KB SRC 4 is selective between Src family members, with >2-fold selectivity over both Lck (Kd, 160 nM) and Fgr (Kd, 240 nM), 8-fold selectivity over c-Yes (Kd, 720 nM), and >40-fold selectivity over Lyn (Kd, 3200 nM), Hck (Kd, 4400 nM), and Fyn (Kd, >40000 nM). KB SRC 4 inhibits the growth of cancer cell lines, with GI50s of 11 μM, 12 μM, 11 μM, 6.0 μM against HT-29, SK-BR-3, MCF7, MDA-MB-453, and NIH-3T3, respectively[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

555.03

Formula

C₃₂H₂₃ClN₈

CAS No.

1380088-03-8

SMILES

NC1=C2C(N(C3=CC=CC(C4=CN=NN4CC5=CC(C6=CC=CC=C6)=CC=C5)=C3)N=C2C7=CC=C(Cl)C=C7)=NC=N1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
KB SRC 4
Cat. No.:
HY-108488
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KB SRC 4

Cat. No.: HY-108488