1325223-34-4
1325223-34-4
Chemical Structure
Pelitinib-d6
- CAS No.: 1325223-34-4
- Formula:C24H17D6ClFN5O2
- Molecular Weight:473.96
IUPAC Name: (E)-4-(bis(methyl-d3)amino)-N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)but-2-enamide
InChIKey: WVUNYSQLFKLYNI-OTHCMBSRSA-N
SMILES: CCOC(C(NC(/C=C/CN(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)=C1)=CC2=C1C(NC3=CC(Cl)=C(C=C3)F)=C(C#N)C=N2
Biological Activity: Pelitinib-d6 (EKB-569-d6) is the deuterium labeled Pelitinib. Pelitinib (EKB-569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively[1][2].
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Pelitinib-d6 | Pelitinib-d6 (EKB-569-d6) is the deuterium labeled Pelitinib. Pelitinib (EKB-569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively. | |||||||||||||||||||||
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Pelitinib (Standard) | ≥98% | Pelitinib (Standard) is the analytical standard of Pelitinib. This product is intended for research and analytical applications. Pelitinib (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively. | ||||||||||||||||||||
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Pelitinib | 98.52% | Pelitinib (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively. | ||||||||||||||||||||
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References
