1. JAK/STAT Signaling
    Protein Tyrosine Kinase/RTK
  2. EGFR
    Src
  3. Pelitinib-d6

Pelitinib-d6 

Cat. No.: HY-32718S
Handling Instructions

Pelitinib-d6 (EKB-569-d6) is the deuterium labeled Pelitinib. Pelitinib (EKB-569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively.

For research use only. We do not sell to patients.

Pelitinib-d6 Chemical Structure

Pelitinib-d6 Chemical Structure

CAS No. : 1325223-34-4

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Description

Pelitinib-d6 (EKB-569-d6) is the deuterium labeled Pelitinib. Pelitinib (EKB-569) is an irreversible inhibitor of EGFR with an IC50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC50s of 282, 800, and 1255 nM, respectively[1][2].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

473.96

Formula

C₂₄H₁₇D₆ClFN₅O₂

CAS No.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Pelitinib-d6
Cat. No.:
HY-32718S
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