2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway
  3. Src Bcr-Abl Pyk2 p38 MAPK c-Kit
  4. Multi-kinase-IN-11

Multi-kinase-IN-11 (Compound 1a) is a DFG-out conformation-targeted multi-kinase inhibitor, including SRC, LCK, ABL, PYK2, CSK, HCK, P38 and C-KIT. Multi-kinase-IN-11 serves as a scaffold for the preparation of fluorescently labeled binding probes and affinity matrices.

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Multi-kinase-IN-11

Multi-kinase-IN-11 Chemical Structure

CAS No. : 1157857-36-7

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Multi-kinase-IN-11 Related Antibodies

Top Publications Citing Use of Products

View All Src Isoform Specific Products:

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Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

View All Bcr-Abl Isoform Specific Products:

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Abl Bcr-Abl

View All p38 MAPK Isoform Specific Products:

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p38 MAPK Akt1 p38α p38β MAPK13 p38δ p38γ

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Description

Multi-kinase-IN-11 (Compound 1a) is a DFG-out conformation-targeted multi-kinase inhibitor, including SRC, LCK, ABL, PYK2, CSK, HCK, P38 and C-KIT. Multi-kinase-IN-11 serves as a scaffold for the preparation of fluorescently labeled binding probes and affinity matrices[1].

Molecular Weight

571.56

Formula

C30H24F3N7O2
CAS No.
SMILES

O=C(NC1=CC=C(C(=C1)NC=2N=CC=CC2C=3N=CN=C(N3)NC4=CC=C(OC)C=C4)C)C5=CC=CC(=C5)C(F)(F)F
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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Multi-kinase-IN-11 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-kinase-IN-111157857-36-7SrcBcr-AblPyk2p38 MAPKc-KitProline-rich tyrosine kinase 2SCFRCD117SRC kinasep38α kinaseLOK kinasec-KITPYK2ABL kinaseDFG-out inactive conformationCSK kinaseLCK kinaseHCK kinaseInhibitorinhibitorinhibit

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