268741-43-1
Chemical Structure
AP22408
- CAS No.: 268741-43-1
- Formula:C30H41N3O10P2
- Molecular Weight:665.61
IUPAC Name: (4-((S)-2-acetamido-3-(((S)-3-carbamoyl-2-(cyclohexylmethoxy)-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-yl)amino)-3-oxopropyl)-1,2-phenylene)bis(phosphonic acid)
InChIKey: SPSGYTWOIGAABK-DQEYMECFSA-N
SMILES: O=C(N[C@H]1CCCCC2=CC(OCC3CCCCC3)=C(C(N)=O)C=C21)[C@@H](NC(C)=O)CC4=CC=C(P(O)(O)=O)C(P(O)(O)=O)=C4
Biological Activity: AP22408 is a nonpeptide inhibitor against Src SH2 with an IC50 value of 0.3 μM. AP22408 inhibits rabbit osteoclast-mediated resorption of dentine, exhibits bone-targeting properties based on a hydroxyapatite adsorption assay and demonstrates in vivo antiresorptive activity in a parathyroid hormone-induced rat model. AP22408 is proming for rasearch of osteoporosis and other bone-related diseases such as Paget’s disease, osteolytic bone metastasis and hypercalcemia associated with malignancy[1].
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AP22408 | AP22408 is a nonpeptide inhibitor against Src SH2 with an IC50 value of 0.3 μM. AP22408 inhibits rabbit osteoclast-mediated resorption of dentine, exhibits bone-targeting properties based on a hydroxyapatite adsorption assay and demonstrates in vivo antiresorptive activity in a parathyroid hormone-induced rat model. AP22408 is proming for rasearch of osteoporosis and other bone-related diseases such as Paget’s disease, osteolytic bone metastasis and hypercalcemia associated with malignancy. | |||||||||||||||||||||
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Keywords
