2. Signaling Pathways
  3. Apoptosis
  4. TNF Receptor
  5. TNFRSF18/GITR/CD357 Isoform
  6. TNFRSF18/GITR/CD357 Activator

TNFRSF18/GITR/CD357 Activator

TNFRSF18/GITR/CD357 Activator (1):

Cat. No. Product Name Effect Purity
  • HY-P992450
    REGN6569
    		Activator
    REGN6569 is a fully human IgG1 monoclonal antibody targeting glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) with high specificity for GITR. REGN6569 exerts stronger in vitro antibody-dependent cell-mediated cytotoxicity (ADCC) against regulatory T cells expressing GITR. REGN6569 selectively depletes regulatory T cells via antibody-dependent cell-mediated cytotoxicity and increases the proportion of proliferative natural killer (NK) cells in peripheral blood. REGN6569 is applicable for advanced solid malignancies. Isotype control: HY-P99001.