Natriuretic Peptide Receptor (NPR) Antagonist
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Natriuretic Peptide Receptor (NPR) Antagonist (2)
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A 71915
0 ImagesA 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells.
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August 31
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August 31
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AP 811
0 ImagesAP 811 is a selective atrial natriuretic peptide clearance receptor (ANP-CR, NPR3) antagonist with a Ki of 0.48 nM. AP 811 displays >20000-fold selectivity for NPR3 over NPR1. AP 811 abolishes ANP-induced pump stimulation.
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August 31
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August 31
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