2. Peptides
  3. A 71915

A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells.

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A 71915 Chemical Structure

A 71915 Chemical Structure

CAS No. : 132956-87-7

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5 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of A 71915:

A 71915 Related Antibodies

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Description

A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells[1].

IC50 & Target

A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist, with a pKi of 9.18.
In Vitro

A 71915 combines to Neuroblastoma NB-OK-1 cells, is used in the Cyclic GMP assay.
A 71915 shifts the ANP dose-response curve of cyclic GMP production to the right[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

A 71915 Related Antibodies
In Vivo

A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching[2].
A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat (Male Sprague-Dawley); weighing 150-180 g[3]
Dosage: 30 μg/kg/day; infused for 3 weeks
Administration: via a mini-osmotic pump
Result: The inhibitory effect of NS-398 on blood pressure was attenuated by the pretreatment with A 71915 (30 μg/kg/day).
Molecular Weight

1613.95

Formula

C69H116N26O15S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Arg-Cys-{Cha}-Gly-Gly-Arg-Ile-Asp-Arg-Ile-{d-Tic}-Arg-Cys-NH2 (Disulfide bridge: Cys2-Cys13)
Sequence Shortening

RC-{Cha}-GGRIDRI-{d-Tic}-RC-NH2 (Disulfide bridge: Cys2-Cys13)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (30.98 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6196 mL 3.0980 mL 6.1960 mL
5 mM 0.1239 mL 0.6196 mL 1.2392 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.6196 mL 3.0980 mL 6.1960 mL 15.4899 mL
5 mM 0.1239 mL 0.6196 mL 1.2392 mL 3.0980 mL
10 mM 0.0620 mL 0.3098 mL 0.6196 mL 1.5490 mL
15 mM 0.0413 mL 0.2065 mL 0.4131 mL 1.0327 mL
20 mM 0.0310 mL 0.1549 mL 0.3098 mL 0.7745 mL
25 mM 0.0248 mL 0.1239 mL 0.2478 mL 0.6196 mL
30 mM 0.0207 mL 0.1033 mL 0.2065 mL 0.5163 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

A 71915132956-87-7A71915A-71915Othershighlypotentcompetitivedose dependentlycGMPNB-OK-1 cellsInhibitorinhibitorinhibit

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