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  2. A 71915

A 71915 

Cat. No.: HY-P2026
Handling Instructions

A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells.

For research use only. We do not sell to patients.

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A 71915 Chemical Structure

A 71915 Chemical Structure

CAS No. : 132956-87-7

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Description

A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist (pKi= 9.18). A 71915 displaces [125I]ANP dose dependently, with a Ki of 0.65 nM. A71915( pA2= 9.48) against rat ANP-induced cGMP production in NB-OK-1 cells[1].

IC50 & Target

A 71915 is a highly potent and competitive natriuretic peptide receptor A (ANP, NPRA) antagonist, with a pKi of 9.18.

In Vitro

A 71915 combines to Neuroblastoma NB-OK-1 cells, is used in the Cyclic GMP assay.
A 71915 shifts the ANP dose-response curve of cyclic GMP production to the right[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A 71915 (5 μl; i.m.; 25-30 g male CD-1 mice) affects BNP (1 nmol)- and GRP (0.1 nmol)-induced scratching[2].
A 71915 (30 μg/ kg/ day) inhibits NS-398 on blood pressure decreased[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat (Male Sprague-Dawley); weighing 150-180 g[3]
Dosage: 30 μg/kg/day; infused for 3 weeks
Administration: via a mini-osmotic pump
Result: The inhibitory effect of NS-398 on blood pressure was attenuated by the pretreatment with A 71915 (30 μg/kg/day).
Molecular Weight

1613.95

Formula

C₆₉H₁₁₆N₂₆O₁₅S₂

CAS No.
Sequence

Arg-Cys-Cha-Gly-Gly-Arg-Ile-Asp-Arg-Ile-D-tic-Arg-Cys-NH2 (Disulfide bridge: Cys2-Cys13)

Sequence Shortening

{RC-Cha}-GGRIDRI-{D-Tic-RC}-NH2 (Disulfide bridge: Cys2-Cys13)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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A 71915
Cat. No.:
HY-P2026
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