1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. AM12

AM12 

Cat. No.: HY-128561
Handling Instructions

AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM.

For research use only. We do not sell to patients.

AM12 Chemical Structure

AM12 Chemical Structure

CAS No. : 2387510-84-9

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Description

AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM[1].

IC50 & Target

IC50: 0.28 μM (TRPC5)[1]

In Vitro

AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A[1].
AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it[1].
AM12 also inhibits Ca2+ entry evoked by Gd3+. AM12 inhibits the Gd3+-evoked Ca2+ signal with an IC50 of 0.28 μM. AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd3+-evoked signal[1].

Molecular Weight

349.13

Formula

C₁₅H₉BrO₅

CAS No.

2387510-84-9

SMILES

O=C1C(O)=C(C2=CC=CC=C2Br)OC3=C1C(O)=CC(O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AM12AM 12AM-12TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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