Cav3 - caveolin 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29161

Summary

Enables several functions, including nitric-oxide synthase binding activity; Potassium Channel Inhibitor activity; and transmembrane transporter binding activity. Involved in several processes, including negative regulation of cell growth involved in cardiac muscle cell development; positive regulation of cellular component organization; and response to ischemia. Located in several cellular components, including T-tubule; cell surface; and neuromuscular junction. Part of protein-containing complex. Colocalizes with several cellular components, including Z disc; intercalated disc; and sarcolemma. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple); isolated elevated serum creatine phosphokinase levels; and muscle tissue disease (multiple). Orthologous to human CAV3 (caveolin 3). [provided by Alliance of Genome Resources, Apr 2022]

Cav3 Products (1)

mRNA Protein Name
NM_019155.2 NP_062028.1 caveolin-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
16479074 RGD
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
15961389 RGD
enables nitric-oxide synthase binding IPI
IPI: Inferred from physical interaction
15007069 RGD
enables potassium channel inhibitor activity IMP
IMP: Inferred from mutant phenotype
22879586 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12649076 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
22879586 RGD
Biological Process GO Annotation Evidence References Source
involved in cell differentiation IEP
IEP: Inferred from expression pattern
16135403 RGD
involved in cellular response to ionomycin IEP
IEP: Inferred from expression pattern
15725944 RGD
involved in negative regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
21170593 RGD
involved in negative regulation of potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
22879586 RGD
involved in negative regulation of potassium ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
22879586 RGD
involved in positive regulation of caveolin-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
22879586 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21508095 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
16318846 RGD
involved in positive regulation of microtubule polymerization IMP
IMP: Inferred from mutant phenotype
16480946 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
29438664 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
29438664 RGD
involved in ventricular cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
22879586 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
9925767 RGD
located in Z disc IDA
IDA: Inferred from direct assay
15980179 RGD
located in caveola IDA
IDA: Inferred from direct assay
9925767 RGD
located in cell surface IDA
IDA: Inferred from direct assay
12649076 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
15961389 RGD
located in neuromuscular junction IDA
IDA: Inferred from direct assay
12923236 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
9925767 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12649076 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
15961389 RGD
located in vesicle IDA
IDA: Inferred from direct assay
11884374 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

caveolin-3

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0166 L-Ascorbic acid 99.97% Unkown
HY-B0166A L-Ascorbic acid sodium salt 99.97% Unkown
HY-B0166R L-Ascorbic acid (Standard) 99.97% Unkown

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-B0166GL L-Ascorbic acid (GMP Like) 99.88% Phase 4
HY-B0166G L-Ascorbic acid (GMP) / Phase 2
HY-115681 (2R/S)-6-PNG Inhibitor 99.96% Phase 1

Pre-clinical Phase

Bioactive Molecules (38)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111828 TTA-A2 Antagonist 99.33% Unkown
HY-B0166S L-Ascorbic acid-13C6 99.90% Unkown
HY-103309 ML218 Inhibitor 99.49% Unkown
HY-132184 5,6-Epoxyeicosatrienoic acid Inhibitor 99.9% Unkown
HY-120597 SAK3 Activator 99.80% Unkown
HY-B0166S6 L-Ascorbic acid-d2 99.90% Unkown
HY-B0166S1 L-Ascorbic acid-13C 99.90% Unkown
HY-P1441A Mambalgin 1 TFA Inhibitor 95.72% Unkown
HY-B0166S8 L-Ascorbic acid-13C6-1 99.37% Unkown
HY-112499S1 Menaquinone-7-13C6 96.0% Unkown
HY-147638 MONIRO-1 Inhibitor 99.18% Unkown
HY-50707 (Rac)-TTA-P2 Control 98.69% Unkown
HY-B0166S3 L-Ascorbic acid-13C-2 95.0% Unkown
HY-103309A ML218 hydrochloride Inhibitor / Unkown
HY-10035A (R)-TTA-P2 Control 99.95% Unkown
HY-103309S ML218-d9 Inhibitor / Unkown
HY-118030 RQ-00311651 Antagonist / Unkown
HY-126336 HM12 Inhibitor / Unkown
HY-129841 Niguldipine monohydrochloride Inhibitor / Unkown
HY-132184S 5,6-Epoxyeicosatrienoic acid-d11 / Unkown
HY-147639 Cav 2.2/3.2 blocker 1 Inhibitor / Unkown
HY-147708 T-Type calcium channel inhibitor 2 Inhibitor / Unkown
HY-151450 Cav 3.2 inhibitor 1 Inhibitor / Unkown
HY-151451 Cav 3.2 inhibitor 2 Inhibitor / Unkown
HY-151452 Cav 3.2 inhibitor 3 Inhibitor / Unkown
HY-154832 Cav 3.2 inhibitor 4 Inhibitor / Unkown
HY-177955 α-Obscurine derivative-1 Inhibitor / Unkown
HY-B0166E L-Ascorbic acid magnesium / Unkown
HY-B0166S2 L-Ascorbic acid-13C-1 99.90% Unkown
HY-B0166S4 L-Ascorbic acid-13C-3 / Unkown
HY-B0166S5 L-Ascorbic acid-13C-4 / Unkown
HY-P5793 GTx1-15 Inhibitor / Unkown
HY-P5869 Kurtoxin / Unkown
HY-RS01988 CAV3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-112499S Menaquinone-7-d7 / Unkown
HY-122201 NSC156529 Antagonist / Unkown
HY-156889 Cav 3.1 blocker 1 Antagonist / Unkown
HY-P3269 Calciseptine Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cav3 NCBI NCBI:859