TDP2 - tyrosyl-DNA phosphodiesterase 2 Gene

Also Known as EAP2; AD022; EAPII; TTRAP; hTDP2; dJ30M3.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51567

About TDP2

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:24,649,979-24,666,899 (from NCBI)

This gene has 5 transcripts (splice variants), 272 orthologues and is associated with 2 phenotypes. Broad expression in small intestine (RPKM 97.5), colon (RPKM 87.6) and 24 other tissues.

Summary

This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF Receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 Endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]

TDP2 Products (1)

mRNA	Protein	Name
NM_016614.3	NP_057698.2	tyrosyl-DNA phosphodiesterase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables 5'-tyrosyl-DNA phosphodiesterase activity	IDA IDA: Inferred from direct assay	19794497	GOA
enables 5'-tyrosyl-DNA phosphodiesterase activity	IMP IMP: Inferred from mutant phenotype	21030584	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	22405347	GOA
enables manganese ion binding	IDA IDA: Inferred from direct assay	22822062	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18039968	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	22822062	GOA
enables tyrosyl-RNA phosphodiesterase activity	IDA IDA: Inferred from direct assay	22908287	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in double-strand break repair	IDA IDA: Inferred from direct assay	19794497	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	21030584	GOA
involved in neuron development	IMP IMP: Inferred from mutant phenotype	24658003	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in PML body	IDA IDA: Inferred from direct assay	19794497	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22908287	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22908287	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TDP2 Protein Structure

UBA_4

Exo_endo_phos

0
100
200
300
362 a.a.

Protein Preferred Names	Protein Names
tyrosyl-DNA phosphodiesterase 2	5'-Tyr-DNA phosphodiesterase

TDP2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TDP2	O95551	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	TDP2	O95551	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	TDP2	O95551	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	TDP2	O95551	BLK	Homo sapiens	P51451	Validated Y2H	32296183
Intra	TDP2	O95551	ATXN3	Homo sapiens	P54252	Y2H Array	32814053
Intra	TDP2	O95551	ATXN3	Homo sapiens	P54252	Validated Y2H	32814053
Intra	TDP2	O95551	ATXN3	Homo sapiens	P54252	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia, Autosomal Recessive 23	SCAR23 Autosomal Recessive Spinocerebellar Ataxia 23 Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Tud Deficiency Autosomal Recessive Cerebellar Ataxia - Epilepsy - Intellectual Disability Syndrome Due To Tud Deficiency Spinocerebellar Ataxia Autosomal Recessive Type 23 Spinocerebellar Ataxia, Autosomal Recessive, 23 Ataxia, Spinocerebellar, Autosomal Recessive, Type 23
Aceruloplasminemia	Cerebellar Ataxia Hypoceruloplasminemia Hemosiderosis, Systemic, Due To Aceruloplasminemia Familial Apoceruloplasmin Deficiency Hereditary Ceruloplasmin Deficiency Deficiency Of Ferroxidase Hypoceruloplasminemia, Hereditary Ceruloplasmin Deficiency Systemic Hemosiderosis Due To Aceruloplasminemia ACERULOP
Spinocerebellar Ataxia Type 1 With Axonal Neuropathy	Scan1 Spinocerebellar Ataxia With Axonal Neuropathy Type 1 Autosomal Recessive Spinocerebellar Ataxia With Axonal Neuropathy Scan1, Tdp1-Related Spinocerebellar Ataxia With Axonal Neuropathy Spinocerebellar Ataxia Autosomal Recessive With Axonal Neuropathy Spinocerebellar Ataxia With Axonal Neuropathy Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy Ataxia, Spinocerebellar, Autosomal Recessive With Axonal Neuropathy
Ruijs-Aalfs Syndrome	Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome RJALS
Reading Disorder	Specific Reading Disorder Reading Dyslexia Developmental Reading Disorder
Paralytic Poliomyelitis	Poliomyelitis, Paralytic
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
Specific Language Impairment	Language Impairment, Specific
Dyslexia
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-162753	ZW-1226	Inhibitor	98.13%	Unkown
HY-RS14333	TDP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TDP2	VGNC	VGNC:35714
Macaca mulatta	TDP2	VGNC	VGNC:78403
Felis catus	TDP2	VGNC	VGNC:97658
Canis familiaris	TDP2	VGNC	VGNC:47219
Mus musculus	TDP2	MGD	MGI:1860486
Rattus norvegicus	TDP2	RGD	RGD:1560342
Others	TDP2	NCBI