CADM3 - cell adhesion molecule 3 Gene

Also Known as BIgR; NECL1; TSLL1; CMT2FF; IGSF4B; Necl-1; synCAM3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57863

About CADM3

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,171,615-159,203,313 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 106.6), placenta (RPKM 39.2) and 4 other tissues.

Summary

The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with Other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]

CADM3 Products (3)

mRNA Protein Name
NM_001127173.3 NP_001120645.1 cell adhesion molecule 3 isoform 2 precursor
NM_001346510.2 NP_001333439.1 cell adhesion molecule 3 isoform 3 precursor
NM_021189.5 NP_067012.1 cell adhesion molecule 3 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CADM3 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (37 - 117)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (135 - 218)

Ig_2

Ig_2: Immunoglobulin domain (237 - 315)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

cell adhesion molecule 3

  • TSLC1-like 1

CADM3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
CADM3 Q8N126 SEC11C Homo sapiens Q9BY50
Y2H Prey Pooling
32296183
Intra
CADM3 Q8N126 SEC11C Homo sapiens Q9BY50
Y2H Array
32296183
Intra
CADM3 Q8N126 SEC11C Homo sapiens Q9BY50
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CADM3 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P70083 CADM3 Protein, Human (HEK293, His) Q8N126-1 (N25-H330) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease, Axonal, Type 2ff

  • CMT2FF

  • Charcot-Marie-Tooth Neuropathy, Type 2ff

  • Charcot-Marie-Tooth Disease 2ff
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

  • Orofacial Cleft 7

  • Zlotogora-Ogur Syndrome

  • CLPED1

  • Ectodermal Dysplasia, Margarita Island Type

  • Ed4

  • Cleft Lip-Palate-Ectodermal Dysplasia Syndrome

  • Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome

  • Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate

  • Ectodermal Dysplasia 4

  • Ectodermal Dysplasia Margarita Type

  • Ectodermal Dysplasia, Type 4

  • Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly

  • Margarita Type Of Ectodermal Dysplasia

  • Zlotogora-Zilberman-Tenenbaum Syndrome

  • Ectd4

  • Ectodermal Dysplasia 4, Hair/Nail Type

  • EDMI

  • Ectodermal Dysplasia Type 4

  • Margarita Island Ectodermal Dysplasia

  • Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate

  • Non-Syndromic Orofacial Cleft 7

  • OFC7

  • Non-Syndromic Cleft Lip/Palate 7

  • Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Charcot-Marie-Tooth Disease

  • Cmt

  • Hmsn

  • Hereditary Motor And Sensory Neuropathy

  • Pma

  • Cmt - Charcot-Marie-Tooth Disease

  • Charcot Marie Tooth Disease

  • Charcot-Marie-Tooth Hereditary Neuropathy

  • Charcot-Marie-Tooth Syndrome

  • Peroneal Muscular Atrophy

  • Hereditary Motor And Sensory Neuropathies
Tooth Disease

  • Tooth Diseases

  • Teeth Disease

  • Tooth Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS18510 Cadm3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01821 CADM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24992 Cadm3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CADM3 RGD RGD:1307035
Mus musculus CADM3 MGD MGI:2137858
Canis familiaris CADM3 VGNC VGNC:38657
Bos taurus CADM3 VGNC VGNC:26696
Macaca mulatta CADM3 VGNC VGNC:70574
Felis catus CADM3 VGNC VGNC:60314
Others CADM3 NCBI