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Art. -Nr.: HY-N18294

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(R,R)-Polysphorin

(R,R)-Polysphorin is a neolignan antimalarial agent that is isolated from the dried leaves and stems of Rhaphidophora decursiva. (R,R)-Polysphorin inhibits the growth of chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum clones in vitro by mediating free radical damage to key cellular components via conjugated double bonds. (R,R)-Polysphorin also exhibits cytotoxicity against human oral epidermoid carcinoma cells.

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CAS. Nr.: 137196-25-9
Formel: C₂₃H₃₀O₇
Molecular Weight:418.48

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

(R,R)-Polysphorin Chemical Structure

CAS. Nr.: 137196-25-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
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Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Plasmodium falciparum sporozoites

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	10 μM Compound: 11	Cytotoxicity against human A549 cells by sulforhodamine B assay Cytotoxicity against human A549 cells by sulforhodamine B assay	[PMID: 21936523]

In Vitro

(R,R)-Polysphorin (Compound 1) (42 h for anti-plasmodium assay; 72 h for cytotoxicity assay) potently inhibits the growth of chloroquine-sensitive (D6) and chloroquine-resistant (W2) Plasmodium falciparum clones, with IC₅₀ values of 404 ng/mL and 368 ng/mL, respectively^[1].
(R,R)-Polysphorin has an ED₅₀ of 2 μg/mL against human oral epidermoid carcinoma cell line KB, with selectivity indices of 5 and 6 for D6 and W2 clones, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

Plasmodium falciparum D6 clone, Plasmodium falciparum W2 clone, human oral epidermoid cancer KB cells
Concentration:

Calibrated to determine IC₅₀/ED₅₀ values
Incubation Time:

42 h (antimalarial assay); 72 h (cytotoxicity assay)
Result:

Inhibited growth of P.falciparum.
falciparum D6 clone with an IC₅₀ of 404 ± 65 ng/mL, inhibited growth of P.falciparum.
falciparum W2 clone with an IC₅₀ of 368 ± 50 ng/mL, induced 50% cytotoxicity in KB cells at an ED₅₀ of 2 μg/mL, and resulted in a selectivity index of 5 for D6 clone and 6 for W2 clone.

Chemical Information

CAS. Nr. 137196-25-9
Molecular Weight 418.48
Formel C₂₃H₃₀O₇
SMILES

O[C@H](C1=CC(OC)=C(C(OC)=C1)OC)[C@@H](C)OC2=C(C=C(C=C2OC)/C=C/C)OC
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang HJ, et al. Antimalarial compounds from Rhaphidophora decursiva. J Nat Prod. 2001;64(6):772-777. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
Chemical Information
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(R,R)-Polysphorin

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Biologische Aktivität

Chemical Information

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Verweise

Calculators

Help & FAQs

(R,R)-Polysphorin Related Classifications

HY-N18294 Related Classifications