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Cat. No.: HY-185280A

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Mocertatug rezetecan (DAR4)

Name: Mocertatug rezetecan (DAR4)
Brand: MedChemExpress
SKU: HY-185280A
Price: 1100.00 USD
Availability: PreOrder

(Synonyms: HS-20089 (DAR4); GSK5733584 (DAR4))

Mocertatug rezetecan (DAR4) (HS-20089 (DAR4); GSK5733584 (DAR4)) is an antibody-drug conjugate (ADC) targeting B7-H4, composed of Mocertatug (HY-P991703) and MC-Gly-Gly-Phe-Gly-(R)-Cyclopropane-Exatecan (HY-148668). Mocertatug rezetecan (DAR4) delivers a TOPO1 inhibitor payload. It binds to B7-H4-expressing tumor cells, triggers ADC internalization, and induces S-phase cell cycle arrest, cytotoxicity, and bystander killing effect. Mocertatug rezetecan (DAR4) exhibits dose-dependent tumor growth inhibition in breast cancer and endometrial cancer CDX models. It can be used in research related to platinum-resistant ovarian cancer, breast cancer, endometrial cancer, cholangiocarcinoma, and cervical cancer.

For research use only. We do not sell to patients.

CAS No.: 3042848-25-6

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mocertatug rezetecan (DAR4) Chemical Structure

CAS No.: 3042848-25-6

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- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target

Topoisomerase I

All Topoisomerase Isoforms :

In Vitro

Mocertatug rezetecan (DAR4) binds concentration-dependently to B7-H4-expressing tumor cells, drives time-dependent B7-H4 internalization and cellular cytotoxicity, induces S-phase cell cycle arrest, and exhibits bystander killing capability^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mocertatug rezetecan (DAR4) exhibits significant and dose-dependent tumor growth inhibition in MX-1 (breast cancer) and RL95-2 (endometrial cancer) CDX models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3042848-25-6
SMILES

[Mocertatug rezetecan (DAR4)]
Synonyms

HS-20089 (DAR4); GSK5733584 (DAR4)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhou L, et al. The role of B7-H4 in ovarian cancer immunotherapy: current status, challenges, and perspectives. Frontiers in immunology. 2024;15:1426050. [Content Brief]

[2]. Wu J, et al. 381O First-in-human/phase I trial of HS-20089, a B7-H4 ADC, in patients with advanced solid tumors[J]. Annals of Oncology, 2023, 34: S336.

[3]. Waight J, et al. Non-clinical characterization of Mocertatug Rezetecan (GSK5733584), a novel B7-H4-directed antibody-drug conjugate[J]. Cancer Research, 2026, 86(7_Supplement): 4575-4575.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Mocertatug rezetecan (DAR4)

All Topoisomerase Isoforms