PI3K-IN-34
PI3K-IN-34 (Compound 6g) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-34 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-34 can be used in leukemia research.
For research use only. We do not sell to patients.
- CAS No.: 2458163-94-3
- Formula: C23H22N6O3
- Molecular Weight:430.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PI3Kα 8.43 μM (IC50) |
PI3Kβ 15.84 μM (IC50) |
PI3Kδ 30.62 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SR | IC50 |
13.59 μM
Compound: Cpd Ib
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Antiproliferative activity against human SR cells assessed as inhibition of cell growth
Antiproliferative activity against human SR cells assessed as inhibition of cell growth
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[PMID: 38389871] |
PI3K-IN-34 (Compound 6g) (10 μM, 48 hours) possess potent antiproliferative activity can inhibit proliferation of Leukemia SR cell lines in vitro[1].
PI3K-IN-34 (Compound 6g) induces cell cycle arrest toward the G2-M phase (45.75%) and leads to DNA synthesis and apoptosis[1].
PI3K-IN-34 (Compound 6g) (10 μM, 48 hours) results in apoptotic with 22.83% of cells in the early and latest age[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Leukemia SR cell lines.
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Concentration:10 μM
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Incubation Time:48 hours
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Result:Antiproliferative activity with values of 4.37 μM.
Chemical Information
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CAS No. 2458163-94-3
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Molecular Weight 430.46
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Formula C23H22N6O3
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SMILES
N#CC1=C(N2CCOCC2)N=C(N/N=C/C3=CC=CC(O)=C3)N=C1C4=CC=C(OC)C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PI3K-IN-34 Related Classifications
HY-147899 Related Classifications
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