2'-deoxynucleoside 5'-phosphate N-hydrolase 1
Definition:
Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.
References:
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[1]. Claire Amiable, et al. N (6)-substituted AMPs inhibit mammalian deoxynucleotide N-hydrolase DNPH1. PLoS One. 2013 Nov 19;8(11):e80755. [Content Brief]
[2]. Claire Amiable, et al. 6-(Hetero)Arylpurine nucleotides as inhibitors of the oncogenic target DNPH1: synthesis, structural studies and cytotoxic activities. Eur J Med Chem. 2014 Oct 6;85:418-37. [Content Brief]
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