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40S ribosomal protein S3

Definition:

Involved in translation as a component of the 40S small ribosomal subunit. Has endonuclease activity and plays a role in repair of damaged DNA. Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA. Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS). Has also been shown to bind with similar affinity to intact and damaged DNA. Stimulates the N-glycosylase activity of the base excision protein OGG1. Enhances the uracil excision activity of UNG1. Also stimulates the cleavage of the phosphodiester backbone by APEX1. When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage. Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide. Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes. Represses its own translation by binding to its cognate mRNA. Binds to and protects TP53/p53 from MDM2-mediated ubiquitination. Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization. Involved in induction of apoptosis through its role in activation of CASP8. Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5. Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation.

References:

[1]. Hag Dong Kim, et al. RpS3 translation is repressed by interaction with its own mRNA. J Cell Biochem. 2010 May 15;110(2):294-303. [Content Brief]

[2]. J Kim, et al. Implication of mammalian ribosomal protein S3 in the processing of DNA damage. J Biol Chem. 1995 Jun 9;270(23):13620-9. [Content Brief]

[3]. Vijay Hegde, et al. Knockdown of ribosomal protein S3 protects human cells from genotoxic stress. DNA Repair (Amst). 2007 Jan 4;6(1):94-9. [Content Brief]

[4]. K E Balyeva, et al. [Interactions of human ribosomal protein S3 with undamaged and damaged DNA]. Mol Biol (Mosk). 2008 Mar-Apr;42(2):314-22. [Content Brief]

[5]. Chang-Young Jang, et al. RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis. FEBS Lett. 2004 Feb 27;560(1-3):81-5. [Content Brief]

[6]. Fengyi Wan, et al. Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. Cell. 2007 Nov 30;131(5):927-39. [Content Brief]

[7]. Vijay Hegde, et al. Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1. Biochemistry. 2004 Nov 9;43(44):14211-7. [Content Brief]

[8]. Sang Hwa Kim, et al. Characterization of a wide range base-damage-endonuclease activity of mammalian rpS3. Biochem Biophys Res Commun. 2005 Mar 25;328(4):962-7. [Content Brief]

[9]. YongJoong Kim, et al. Cytoplasmic ribosomal protein S3 (rpS3) plays a pivotal role in mitochondrial DNA damage surveillance. Biochim Biophys Acta. 2013 Dec;1833(12):2943-2952. [Content Brief]

[10]. Sung Il Ko, et al. Human ribosomal protein S3 (hRpS3) interacts with uracil-DNA glycosylase (hUNG) and stimulates its glycosylase activity. Mutat Res. 2008 Dec 15;648(1-2):54-64. [Content Brief]

[11]. Sang Bae Lee, et al. Ribosomal protein S3, a new substrate of Akt, serves as a signal mediator between neuronal apoptosis and DNA repair. J Biol Chem. 2010 Sep 17;285(38):29457-68. [Content Brief]

[12]. Sridevi Yadavilli, et al. Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain. DNA Repair (Amst). 2009 Oct 2;8(10):1215-24. [Content Brief]

[13]. Chang-Young Jang, et al. Ribosomal protein S3 interacts with TRADD to induce apoptosis through caspase dependent JNK activation. Biochem Biophys Res Commun. 2012 May 11;421(3):474-8. [Content Brief]

[14]. S N Vladimirov, et al. Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry. Eur J Biochem. 1996 Jul 1;239(1):144-9. [Content Brief]

[15]. Vijay Hegde, et al. Characterization of human ribosomal protein S3 binding to 7,8-dihydro-8-oxoguanine and abasic sites by surface plasmon resonance. DNA Repair (Amst). 2004 Feb 3;3(2):121-6. [Content Brief]

[16]. Chang-Young Jang, et al. Ribosomal protein S3 localizes on the mitotic spindle and functions as a microtubule associated protein in mitosis. Biochem Biophys Res Commun. 2012 Dec 7;429(1-2):57-62. [Content Brief]

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