Actin-histidine N-methyltransferase

Definition:

Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'. Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin.

References:

[1]. Qiong Guo, et al. Structural insights into SETD3-mediated histidine methylation on β-actin. Elife. 2019 Feb 20;8:e43676. [Content Brief]

[2]. Sebastian Kwiatkowski, et al. SETD3 protein is the actin-specific histidine N-methyltransferase. Elife. 2018 Dec 11;7:e37921. [Content Brief]

[3]. Yihui Zheng, et al. Molecular basis for histidine N3-specific methylation of actin H73 by SETD3. Cell Discov. 2020 Jan 21;6:3. [Content Brief]

[4]. Alex W Wilkinson, et al. SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature. 2019 Jan;565(7739):372-376. [Content Brief]

[5]. Shaobo Dai, et al. Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun. 2019 Aug 6;10(1):3541. [Content Brief]

Biomedical Dictionary

The Biomedical Dictionary is a comprehensive and professional collection of biological academic terms and subject datas. All explanations are supported by authoritative books or high impact factor literatures, and you can acquire accurate explanations of the biomedical terms you want to know.

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #

Name
Email *

	Sorry, but the email address you supplied was invalid.