ADP-ribosylation factor-binding protein GGA1

Definition

Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Required for targeting PKD1:PKD2 complex from the trans-Golgi network to the cilium membrane (By similarity). Regulates retrograde transport of proteins such as phosphorylated form of BACE1 from endosomes to the trans-Golgi network.

References:

[1]. R Puertollano, et al. The GGAs promote ARF-dependent recruitment of clathrin to the TGN. Cell. 2001 Apr 6;105(1):93-102. [Content Brief]

[2]. Xiangyuan He, et al. GGA proteins mediate the recycling pathway of memapsin 2 (BACE). J Biol Chem. 2005 Mar 25;280(12):11696-703. [Content Brief]

[3]. Maoxiang Zhang, et al. Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2. Sci Rep. 2016 Nov 30;6:37921. [Content Brief]

[4]. Tina Wahle, et al. GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Mol Cell Neurosci. 2005 Jul;29(3):453-61. [Content Brief]

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