Alanine--tRNA ligase, cytoplasmic
Definition:
References:
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[1]. Litao Sun, et al. Evolutionary Gain of Alanine Mischarging to Noncognate tRNAs with a G4:U69 Base Pair. J Am Chem Soc. 2016 Oct 5;138(39):12948-12955. [Content Brief]
[2]. Elena Botta, et al. Protein instability associated with AARS1 and MARS1 mutations causes trichothiodystrophy. Hum Mol Genet. 2021 Aug 28;30(18):1711-1720. [Content Brief]
[3]. Litao Sun, et al. Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14300-14305. [Content Brief]
[4]. Tojo Nakayama, et al. Deficient activity of alanyl-tRNA synthetase underlies an autosomal recessive syndrome of progressive microcephaly, hypomyelination, and epileptic encephalopathy. Hum Mutat. 2017 Oct;38(10):1348-1354. [Content Brief]
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