ALK and LTK ligand 1

Definition

Cytokine that acts as a physiological ligand for receptor tyrosine kinase LTK, leading to its activation. Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation. In contrast to ALKAL2, does not act as a potent physiological ligand for ALK.

References:

[1]. Jikui Guan, et al. FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase. Elife. 2015 Sep 29;4:e09811. [Content Brief]

[2]. Steven De Munck, et al. Structural basis of cytokine-mediated activation of ALK family receptors. Nature. 2021 Dec;600(7887):143-147. [Content Brief]

[3]. Andrey V Reshetnyak, et al. Mechanism for the activation of the anaplastic lymphoma kinase receptor. Nature. 2021 Dec;600(7887):153-157. [Content Brief]

[4]. Hongbing Zhang, et al. Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15741-5. [Content Brief]

[5]. Andrey V Reshetnyak, et al. Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15862-7. [Content Brief]

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