Alkaline ceramidase 3
Definition:
References:
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[1]. Ruijuan Xu, et al. Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes. FASEB J. 2010 Jul;24(7):2507-15. [Content Brief]
[2]. Simon Edvardson, et al. Deficiency of the alkaline ceramidase ACER3 manifests in early childhood by progressive leukodystrophy. J Med Genet. 2016 Jun;53(6):389-96. [Content Brief]
[3]. Ieva Vasiliauskaité-Brooks, et al. Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy. Nat Commun. 2018 Dec 21;9(1):5437. [Content Brief]
[4]. C Mao, et al. Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide. J Biol Chem. 2001 Jul 13;276(28):26577-88. [Content Brief]
[5]. Wei Hu, et al. Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis. J Biol Chem. 2010 Mar 12;285(11):7964-76. [Content Brief]
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