Angiomotin-like protein 1

Definition:

Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus.

References:

[1]. Zhiqiang Li, et al. The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish. J Biol Chem. 2012 Apr 13;287(16):13005-15. [Content Brief]

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