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Angiomotin-like protein 2

Definition:

Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.

References:

[1]. Huizhe Huang, et al. Amotl2 is essential for cell movements in zebrafish embryo and regulates c-Src translocation. Development. 2007 Mar;134(5):979-88. [Content Brief]

[2]. Zhiqiang Li, et al. The Amotl2 gene inhibits Wnt/β-catenin signaling and regulates embryonic development in zebrafish. J Biol Chem. 2012 Apr 13;287(16):13005-15. [Content Brief]

[3]. Yeqi Wang, et al. Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis. J Biol Chem. 2011 Nov 25;286(47):41095-104. [Content Brief]

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