Anoctamin-2

Definition:

Calcium-activated chloride channel (CaCC) which may play a role in olfactory signal transduction. Odorant molecules bind to odor-sensing receptors (OSRs), leading to an increase in calcium entry that activates CaCC current which amplifies the depolarization of the OSR cells, ANO2 seems to be the underlying chloride channel involved in this process. May mediate light perception amplification in retina.

References:

[1]. Rainer Schreiber, et al. Expression and function of epithelial anoctamins. J Biol Chem. 2010 Mar 5;285(10):7838-45. [Content Brief]

[2]. Paolo Scudieri, et al. The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels. Exp Physiol. 2012 Feb;97(2):177-83. [Content Brief]

[3]. Simone Pifferi, et al. Anoctamin 2/TMEM16B: a calcium-activated chloride channel in olfactory transduction. Exp Physiol. 2012 Feb;97(2):193-9. [Content Brief]

[4]. Heidi Stöhr, et al. TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals. J Neurosci. 2009 May 27;29(21):6809-18. [Content Brief]

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