Anthrax toxin receptor 1

Definition:

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.; (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis.

References:

[1]. K A Bradley, et al. Identification of the cellular receptor for anthrax toxin. Nature. 2001 Nov 8;414(6860):225-9. [Content Brief]

[2]. Heather M Scobie, et al. Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5170-4. [Content Brief]

[3]. Kylie A Hotchkiss, et al. TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen. Exp Cell Res. 2005 Apr 15;305(1):133-44. [Content Brief]

[4]. Sheng Fu, et al. The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin. PLoS One. 2010 Jun 18;5(6):e11203. [Content Brief]

[5]. Erica Werner, et al. Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton. J Biol Chem. 2006 Aug 11;281(32):23227-36. [Content Brief]

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