AP-4 complex accessory subunit RUSC1

Definition:

Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Signaling adapter which plays a role in neuronal differentiation. Involved in regulation of NGF-dependent neurite outgrowth. May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (By similarity). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway.

References:

[1]. Gennaro Napolitano, et al. NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein. J Cell Physiol. 2009 Aug;220(2):410-7. [Content Brief]

[2]. Alexandra K Davies, et al. AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A. Nat Commun. 2018 Sep 27;9(1):3958. [Content Brief]

[3]. James I S MacDonald, et al. Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth. J Cell Biol. 2004 Mar 15;164(6):851-62. [Content Brief]

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