ATP synthase subunit C lysine N-methyltransferase

Definition

Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. Promotes chronic pain. Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia.

References:

[1]. Hanneke L D M Willemen, et al. Identification of FAM173B as a protein methyltransferase promoting chronic pain. PLoS Biol. 2018 Feb 14;16(2):e2003452. [Content Brief]

[2]. Jędrzej M Małecki, et al. Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase. J Biol Chem. 2019 Jan 25;294(4):1128-1141. [Content Brief]

生物医学辞典

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