C-myc promoter-binding protein

Definition

Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter.

References:

[1]. Shin-ichiro Yoshimura, et al. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. J Cell Biol. 2010 Oct 18;191(2):367-81. [Content Brief]

[2]. Y Z Stasiv, et al. Cloning of a cDNA encoding a human protein which binds a sequence in the c-myc gene similar to the interferon-stimulated response element. Gene. 1994 Aug 5;145(2):267-72. [Content Brief]

生物医学辞典

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