Calpain-3

Definition:

Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1 at 'His-409'. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53.

References:

[1]. Ting Tao, et al. Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. Cell Res. 2013 May;23(5):620-34. [Content Brief]

[2]. Yihong Guan, et al. Phosphorylation of Def Regulates Nucleolar p53 Turnover and Cell Cycle Progression through Def Recruitment of Calpain3. PLoS Biol. 2016 Sep 22;14(9):e1002555. [Content Brief]

[3]. Yasuko Ono, et al. PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1. J Mol Biol. 2013 Aug 23;425(16):2955-72. [Content Brief]

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