Calsenilin

Definition:

Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity).; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.; May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation.

References:

[1]. D G Jo, et al. Pro-apoptotic function of calsenilin/DREAM/KChIP3. FASEB J. 2001 Mar;15(3):589-91. [Content Brief]

[2]. W F An, et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature. 2000 Feb 3;403(6769):553-6. [Content Brief]

[3]. C Lilliehook, et al. Calsenilin enhances apoptosis by altering endoplasmic reticulum calcium signaling. Mol Cell Neurosci. 2002 Apr;19(4):552-9. [Content Brief]

[4]. Kumud Kunjilwar, et al. KChIP3 rescues the functional expression of Shal channel tetramerization mutants. J Biol Chem. 2004 Dec 24;279(52):54542-51. [Content Brief]

[5]. Henry H Jerng, et al. Multiprotein assembly of Kv4.2, KChIP3 and DPP10 produces ternary channel complexes with ISA-like properties. J Physiol. 2005 Nov 1;568(Pt 3):767-88. [Content Brief]

[6]. J D Buxbaum, et al. Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nat Med. 1998 Oct;4(10):1177-81. [Content Brief]

[7]. Riichi Shibata, et al. A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. J Biol Chem. 2003 Sep 19;278(38):36445-54. [Content Brief]

[8]. Henry H Jerng, et al. Multiple Kv channel-interacting proteins contain an N-terminal transmembrane domain that regulates Kv4 channel trafficking and gating. J Biol Chem. 2008 Dec 19;283(51):36046-59. [Content Brief]

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