Cardiolipin synthase

Definition:

Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions.

References:

[1]. Biao Lu, et al. Cloning and characterization of a cDNA encoding human cardiolipin synthase (hCLS1). J Lipid Res. 2006 Jun;47(6):1140-5. [Content Brief]

[2]. Riekelt H Houtkooper, et al. Identification and characterization of human cardiolipin synthase. FEBS Lett. 2006 May 29;580(13):3059-64. [Content Brief]

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