Cell division cycle 5-like protein

Definition:

DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR).

References:

[1]. Xiaofeng Zhang, et al. An Atomic Structure of the Human Spliceosome. Cell. 2017 May 18;169(5):918-929.e14. [Content Brief]

[2]. Xiechao Zhan, et al. Structure of a human catalytic step I spliceosome. Science. 2018 Feb 2;359(6375):537-545. [Content Brief]

[3]. Michael Grote, et al. Molecular architecture of the human Prp19/CDC5L complex. Mol Cell Biol. 2010 May;30(9):2105-19. [Content Brief]

[4]. Xiaofeng Zhang, et al. Structure of the human activated spliceosome in three conformational states. Cell Res. 2018 Mar;28(3):307-322. [Content Brief]

[5]. Karl Bertram, et al. Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Nature. 2017 Feb 16;542(7641):318-323. [Content Brief]

[6]. Remo Gräub, et al. Cell cycle-dependent phosphorylation of human CDC5 regulates RNA processing. Cell Cycle. 2008 Jun 15;7(12):1795-803. [Content Brief]

[7]. David Haselbach, et al. Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex. Cell. 2018 Jan 25;172(3):454-464.e11. [Content Brief]

[8]. Xiaofeng Zhang, et al. Structures of the human spliceosomes before and after release of the ligated exon. Cell Res. 2019 Apr;29(4):274-285. [Content Brief]

[9]. X H Lei, et al. Human Cdc5, a regulator of mitotic entry, can act as a site-specific DNA binding protein. J Cell Sci. 2000 Dec;113 Pt 24:4523-31. [Content Brief]

[10]. C G Burns, et al. Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13789-94. [Content Brief]

[11]. H S Bernstein, et al. A mammalian homolog of fission yeast Cdc5 regulates G2 progression and mitotic entry. J Biol Chem. 1998 Feb 20;273(8):4666-71. [Content Brief]

[12]. Deana Leonard, et al. hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing. Biochem Biophys Res Commun. 2003 Sep 5;308(4):793-801. [Content Brief]

[13]. P Ajuh, et al. Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry. EMBO J. 2000 Dec 1;19(23):6569-81. [Content Brief]

[14]. R Ohi, et al. Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes. Mol Cell Biol. 1998 Jul;18(7):4097-108. [Content Brief]

[15]. Melissa S Jurica, et al. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. RNA. 2002 Apr;8(4):426-39. [Content Brief]

[16]. H S Bernstein, et al. Pombe Cdc5-related protein. A putative human transcription factor implicated in mitogen-activated signaling. J Biol Chem. 1997 Feb 28;272(9):5833-7. [Content Brief]

[17]. Sebastian M Fica, et al. A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation. Science. 2019 Feb 15;363(6428):710-714. [Content Brief]

[18]. Alexandre Maréchal, et al. PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry. Mol Cell. 2014 Jan 23;53(2):235-246. [Content Brief]

[19]. P Ajuh, et al. A direct interaction between the carboxyl-terminal region of CDC5L and the WD40 domain of PLRG1 is essential for pre-mRNA splicing. J Biol Chem. 2001 Nov 9;276(45):42370-81. [Content Brief]

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