Chromodomain-helicase-DNA-binding protein 6

Definition:

DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.; (Microbial infection) Acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner.

References:

[1]. Paul Nioi, et al. The carboxy-terminal Neh3 domain of Nrf2 is required for transcriptional activation. Mol Cell Biol. 2005 Dec;25(24):10895-906. [Content Brief]

[2]. Jasmin Fertey, et al. Interaction of the papillomavirus E8--E2C protein with the cellular CHD6 protein contributes to transcriptional repression. J Virol. 2010 Sep;84(18):9505-15. [Content Brief]

[3]. Roberto Alfonso, et al. CHD6, a cellular repressor of influenza virus replication, is degraded in human alveolar epithelial cells and mice lungs during infection. J Virol. 2013 Apr;87(8):4534-44. [Content Brief]

[4]. Roberto Alfonso, et al. CHD6 chromatin remodeler is a negative modulator of influenza virus replication that relocates to inactive chromatin upon infection. Cell Microbiol. 2011 Dec;13(12):1894-906. [Content Brief]

[5]. Benjamin J Manning, et al. The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities. J Biol Chem. 2017 Jul 14;292(28):11927-11936. [Content Brief]

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