Cobalamin trafficking protein CblD

Definition:

Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.

References:

[1]. David Coelho, et al. Gene identification for the cblD defect of vitamin B12 metabolism. N Engl J Med. 2008 Apr 3;358(14):1454-64. [Content Brief]

[2]. Jehona Jusufi, et al. Characterization of functional domains of the cblD (MMADHC) gene product. J Inherit Metab Dis. 2014 Sep;37(5):841-9. [Content Brief]

[3]. Carmen Gherasim, et al. The C-terminal domain of CblD interacts with CblC and influences intracellular cobalamin partitioning. Biochimie. 2013 May;95(5):1023-32. [Content Brief]

[4]. Christine Bassila, et al. Methionine synthase and methionine synthase reductase interact with MMACHC and with MMADHC. Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):103-112. [Content Brief]

[5]. Kazuhiro Yamada, et al. Structure of Human B12 Trafficking Protein CblD Reveals Molecular Mimicry and Identifies a New Subfamily of Nitro-FMN Reductases. J Biol Chem. 2015 Dec 4;290(49):29155-66. [Content Brief]

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