Coiled-coil domain-containing protein 3

Definition:

Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs. Positively regulates lipid accumulation in adipose cells (By similarity).

References:

[1]. Abul Kalam Azad, et al. Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis factor-α/nuclear factor κB-induced endothelial inflammation. Cell Signal. 2014 Dec;26(12):2793-800. [Content Brief]

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