Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Definition:
As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP.
References:
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[1]. Kota N Gopalakrishna, et al. Mechanisms of mutant PDE6 proteins underlying retinal diseases. Cell Signal. 2017 Sep;37:74-80. [Content Brief]
[2]. Tanja Grau, et al. Decreased catalytic activity and altered activation properties of PDE6C mutants associated with autosomal recessive achromatopsia. Hum Mol Genet. 2011 Feb 15;20(4):719-30. [Content Brief]
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