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Congenital mirror movements

Definition:

Mirror movements (MRMV) are involuntary movements of one side of the body that mirror intentional movements on the opposite side. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Congenital mirror movements is a rare disorder that is mainly inherited in an autosomal-dominant fashion. Mutations in DCC, the gene encoding receptor for netrin 1 have been identified in MRMV patients. It has also been reported that RAD51 haploinsufficiency causes the heterogeneous MRMV.

References:

[1]. Aurélie Méneret, et al. Mutations in the netrin-1 gene cause congenital mirror movements. J Clin Invest. 2017 Nov 1;127(11):3923-3936. [Content Brief]

[2]. Christel Depienne, et al. RAD51 haploinsufficiency causes congenital mirror movements in humans. Am J Hum Genet. 2012 Feb 10;90(2):301-7. [Content Brief]

[3]. Iltaf Ahmed, et al. Identification of a homozygous splice site mutation in the dynein axonemal light chain 4 gene on 22q13.1 in a large consanguineous family from Pakistan with congenital mirror movement disorder. Hum Genet. 2014 Nov;133(11):1419-29. [Content Brief]

[4]. Myriam Srour, et al. Mutations in DCC cause congenital mirror movements. Science. 2010 Apr 30;328(5978):592. [Content Brief]

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