COUP transcription factor 1

Definition:

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG.

References:

[1]. Y Zhang, et al. EAR2 and EAR3/COUP-TFI regulate transcription of the rat LH receptor. Mol Endocrinol. 2001 Nov;15(11):1891-905. [Content Brief]

[2]. Y Zhang, et al. Nuclear orphan receptors regulate transcription of the gene for the human luteinizing hormone receptor. J Biol Chem. 2000 Jan 28;275(4):2763-70. [Content Brief]

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