2. Biology Dictionary
  3. Cyclic nucleotide phosphodiesterases (PDEs)

Cyclic nucleotide phosphodiesterases (PDEs)

Definition:

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that have the unique function of terminating cyclic nucleotide signaling by catalyzing the hydrolysis of cAMP and GMP. They are critical regulators of the intracellular concentrations of cAMP and cGMP as well as of their signaling pathways and downstream biological effects.

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