Cytochrome c oxidase copper chaperone

Definition:

Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).

References:

[1]. C Oswald, et al. Knockdown of human COX17 affects assembly and supramolecular organization of cytochrome c oxidase. J Mol Biol. 2009 Jun 12;389(3):470-9. [Content Brief]

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